You are the anesthesiologist on call. A 48-year-old patient, Čeněk Dostál (82 kg), with a humeral fracture following a fall, has been brought to the operating room and is indicated for urgent osteosynthesis of the humerus.
The patient is conscious and cooperative. You plan to perform the procedure under general anesthesia combined with a peripheral nerve block of the brachial plexus to reduce perioperative pain.
Which principles of safe administration of local anesthetics during peripheral nerve block in an adult patient are essential to minimize the risk of local anesthetic systemic toxicity (LAST)?
