TTP
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease that requires prompt diagnosis and immediate treatment. This interactive algorithm will guide you through all the key steps - from the first symptoms, especially neurological, through differential diagnosis and evaluation of laboratory findings, to the choice of acute therapy, management of complications and identifying the underlying cause. TTP is a rare disease, but its early recognition is essential. Only those who know the diagnosis can make the right decision - and thanks to our algorithm, that could be you!
Review
Sources
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https://mzd.gov.cz/wp-content/uploads/2021/08/Metodick%c3%bd-pokyn-p%c3%a9%c4%8de-o-pacienty-s-CMP.pdf
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Learning targets
2. The student can recognize TTP as an acute, life-threatening condition and knows the principles of early diagnosis and differential diagnosis.
3. The student knows the management and treatment of the patient with TTP and understands the contraindications to certain procedures that may worsen the course of the disease or endanger the patient's life.
Key points
2. It is caused by a deficiency of the enzyme ADAMTS13, leading to the formation of microthrombi
3. When TTP is suspected, it is essential not to administer platelet transfusion products and to transport the patient immediately to a hematology care center
4. Treatment includes plasmapheresis, corticosteroids and caplacizumab
