Racional antibiotic therapy

The antibiotic therapy is an important part of care in all medical specialities. That's why it is necessary to know the general principles. The treatment should be efficient enough, but targeted at the same time. It's essential to think about risks of developing bacterial resistence. This algorithm will lead you through case of a concrete patient, from indication of the therapy to the solution of complications.

Published at: 28.4.2016


Alena Ševčíková, MD
Chief of Clinical Microbiology Department, University Hospital Brno, Brno, Czech Republic

Inclusion of interactive algorithm "Rational antibiotic therapy" for teaching in the context of emergency conditions is very beneficial. The important steps are outlined as follows: correct diagnostic procedure in suspected sepsis, emphasis on timely collection of clinical material samples and immediate administration of antibiotics. The algorithm highlights the importance of a timely and judicious choice of antibiotics with narrow spectrum of activity in the community acquired infection that produces less selection pressure for the emergence of antibiotic resistance than broad-spectrum antibiotics. The other steps are not forgotten; even today is relatively frequently presented severe complication of treatment with antibiotics - pseudomembranous colitis caused by toxigenous strain of Clostridium difficile. The algorithm shows the correct diagnostic procedure when suspecting this disease and choice of appropriate therapy.


VOTAVA, Miroslav. Lékařská mikrobiologie obecná. 2. přeprac. vyd. Brno, 2005. ISBN 80-868-5000-5.

Doporučený postup diagnostiky a léčby kolitidy vyvolané Clostridium difficile garantuje Společnost infekčního lékařství ČLS JEP, Společnost pro epidemiologii a mikrobiologii ČLS JEP a Společnost pro lékařskou mikrobiologii ČLS JEP In: Klinická mikrobiologie a infekční lékařství 2/2014 s. 56-66 ISSN1211-264X

European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection In: Clinical Microbiology and Infection, Volume 20, Issue suplement s2, s. 1-26

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