Sepsis is systemic inflammatory response syndrome of organism caused by infection. It can easily extend to a stage of severe sepsis and septic shock with the signs of multiple organ dysfunction even failure requiring extensive organ functions´ support . Increasing number of septic patients revers to the fact that the amount of predisposed individuals in various ways is increasing: patients suffering from imunosupression, undergoing invasive diagnostic and therapeutic procedures. Early diagnose and immediate and accurate therapy is crucial.
You are guided by authors of this algorithm clearly and by logical steps through current views on therapy and diagnostics of severe sepsis and septic shock. Presented algorithm is an updated version of the older one from 2010. Despite some partial changes, the main columns of diagnostics and therapy of severe sepsis remain unchanged. It is important to emphasize the importance of fast diagnostics and quick and appropriate therapy, which can stop the progress of sepsis into severe sepsis. It is still valid, that there are antibiotics and fluid resuscitation in the therapy of sepsis on the first place. Regrettably you can still see in a clinical praxis an opportunistic aproach, e.g. late administration of antibiotics or ignoring of a disproportion between capacity and filling of blood stream in a septic state. This algorithm incorporates all these ideas and in my opinion it is a benefit to every clinician.
QUARTIN, Andrew A., Roland M. H. SCHEIN, Daniel H. KETT a Peter N. PEDUZZI. Veľkosť a trvanie vplyvu sepsy na prežívanie. JAMA. 1997, 5(7/8), 519-525. ISSN 1210-4132.
NOVÁK, Ivan, Karel CVACHOVEC a Vladimír ČERNÝ, ed. Sepse v intenzivní péči: vybraná doporučení v diagnostice a terapii. Praha: Maxdorf, 2002. ISBN 8085912740.