Surviving sepsis - first hour

Marek Kovář, MD, Lucie Bánovská, Veronika Kočí. Illustration: Veronika Kočí

Sepsis is a life-threatening dysregulated response of the organism to an infectious stimulus that persists even after removal of this stimulus. Sepsis can occur very quickly and severely, under the picture of septic shock with multiorgan failure and the need for organ function support. Therefore, early recognition of this critical condition and early initiation of treatment should be considered. In treatment, emphasis is placed on initiating it within the first hour of suspected sepsis to maximize the patient's chances of recovery. 

nosocomial sepsis
Published at: 21.5.2019


Assoc. Prof. Jan Máca, MD, PhD
Deputy Head of the Department for science and education of Anaesthesiology, Resuscitation and Intensive Medicine, University Hospital Ostrava, Czech Republic

Sepsis is a serious life-threatening condition characterized by the presence of organ dysfunctions arising from the dysregulated host response to infection. The view of sepsis has evolved rapidly in recent decades. Mainly it is due to the increasing knowledge about its epidemiology, pathophysiology and therapy. As a result of population aging, increasing number of co-morbidities and improved diagnosis, the incidence of sepsis is increasing. Although sepsis is one of the most important topics and critical areas in intensive care, general and professional awareness remains inadequate. In 2016, a new definition of sepsis (sepsis-3) and a 5th revision of the Surviving Sepsis Campaign were recommended for intensive care patients with sepsis and septic shock. The presented algorithm is a necessary and clear knowhow to what to hold and what to think of a patient with sepsis. It highlights the need for rapid identification of the diagnosis and pathological agent and early initiation of supportive and causal treatment of sepsis.


RHODES, Andrew, Laura E. EVANS, Waleed ALHAZZANI, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Critical Care Medicine [online]. 2017, march 2017, 45(3), 67 [cit. 2019-03-17]. DOI: 10.1097/CCM.0000000000002255. ISSN 0090-3493. Available at:

SINGER, Mervyn, Clifford S. DEUTSCHMAN, Christopher Warren SEYMOUR, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA [online]. 2016, march 2017, 315(8), 486-552 [cit. 2019-03-17]. DOI: 10.1001/jama.2016.0287. ISSN 0098-7484. Available at:

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